miR-191 and miR-135 are required for long-lasting spine remodelling associated with synaptic long-term depression

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miR-191 and miR-135 are required for long-lasting spine remodeling associated with synaptic long term depression

Activity-dependent modification of dendritic spines, subcellular compartments accommodating postsynaptic specializations in the brain, is an important cellular mechanism for brain development, cognition and synaptic pathology of brain disorders. NMDA receptor-dependent long-term depression (NMDAR-LTD), a prototypic form of synaptic plasticity, is accompanied by prolonged remodelling of spines. ...

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Long-term potentiation (LTP) is a form of synaptic plasticity that results in enhanced synaptic strength. It is associated with the formation and enlargement of dendritic spines-tiny protrusions accommodating excitatory synapses. Both LTP and spine remodelling are crucial for brain development, cognition and the pathophysiology of neurological disorders. The role of microRNAs (miRNAs) in the ma...

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Long Lasting Protein Synthesis- and Activity-Dependent Spine Shrinkage and Elimination after Synaptic Depression

Neuronal circuits modify their response to synaptic inputs in an experience-dependent fashion. Increases in synaptic weights are accompanied by structural modifications, and activity dependent, long lasting growth of dendritic spines requires new protein synthesis. When multiple spines are potentiated within a dendritic domain, they show dynamic structural plasticity changes, indicating that sp...

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Synaptic mechanisms for long-term depression.

Neural networks that store information at synapses rely on mechanisms for increasing and decreasing synaptic strengths. In 1973 Bliss and Lramo reported that stimulating the perforant pathway projecting to the hippocam pus with a high ,frequency tetanus resulted in a rapid and persistent elevation. of the synaptic efficacy [ 11. This form of long-term potent&ion (LTP) lasts for many hours in sl...

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Long-lasting inhibitory synaptic depression is age- and calcium-dependent.

The developmental refinement of excitatory synapses is often influenced by neuronal activity, and underlying synaptic mechanisms have been suggested. In contrast, few studies have asked whether inhibitory synapses are reorganized during development and whether this is accompanied by use-dependent changes of inhibitory synaptic strength. The topographic inhibitory projection from the medial nucl...

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ژورنال

عنوان ژورنال: Nature Communications

سال: 2014

ISSN: 2041-1723

DOI: 10.1038/ncomms4263